Polyclonal Antibody to IRF-3 (Ab-396)
Product Sizes
50 µl
£511.00
35-1849-50UL
100 µl
£581.00
35-1849-100UL
About this Product
- SKU:
- 35-1849
- Additional Names:
- interferon regulatory factor 3
- Clonality:
- Polyclonal
- Extra Details:
- Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection; double-stranded RNA (dsRNA); or toll-like receptor (TLR) signaling; becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change; leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1); a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.394-398(H-I-S-N-S) derived from Human IRF-3.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
