Polyclonal Antibody to Twist1
Product Sizes
50 µl
£512.00
35-1810-50UL
100 µl
£581.00
35-1810-100UL
About this Product
- SKU:
- 35-1810
- Additional Names:
- SCS|| ACS3|| CRS1|| BPES2|| BPES3
- Clonality:
- Polyclonal
- Extra Details:
- Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins; inhibiting trans-activation by MEF2; and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially; depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation. Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity."Sosic D.; Richardson J.A.; Yu K.; Ornitz D.M.; Olson E.N.Cell 112:169-180(2003)
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.18~22(S-N-S-E-E) derived from Human Twist1
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
