Polyclonal Antibody to TIF1beta
Product Sizes
50 µl
£511.00
35-1803-50UL
100 µl
£581.00
35-1803-100UL
About this Product
- SKU:
- 35-1803
- Additional Names:
- KAP1||RNF96
- Clonality:
- Polyclonal
- Extra Details:
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3; a subunit of the nucleosome remodeling and deacetylation (NuRD) complex; and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me; the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac; respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.827~831 (L-S-G-G-P) derived from Human TIF1b.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
