Polyclonal Antibody to TAZ
Product Sizes
50 µl
£511.00
35-1802-50UL
100 µl
£581.00
35-1802-100UL
About this Product
- SKU:
- 35-1802
- Additional Names:
- WWTR1
- Clonality:
- Polyclonal
- Extra Details:
- Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2; in complex with its regulatory protein SAV1; phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1; which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal; promotes cell proliferation and epithelial-mesenchymal transition.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.386~390 (V-E-S-A-L) derived from Human TAZ.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
