Polyclonal Antibody to Ring1A
Product Sizes
50 µl
£511.00
35-1797-50UL
100 µl
£581.00
35-1797-100UL
About this Product
- SKU:
- 35-1797
- Additional Names:
- RNF1|| RING1
- Clonality:
- Polyclonal
- Extra Details:
- Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A; thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex; a complex required to maintain the transcriptionally repressive state of many genes; including Hox genes; throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones; rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2; it does not have the main E3 ubiquitin ligase activity on histone H2A; and it may rather act as a modulator of RNF2/RING2 activity.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.35~39( I-A-V-S-P) derived from Human Ring1A.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
