Polyclonal Antibody to LIN28B
Product Sizes
50 µl
£511.00
35-1795-50UL
100 µl
£581.00
35-1795-100UL
About this Product
- SKU:
- 35-1795
- Additional Names:
- CSDD2|| FLJ16517
- Clonality:
- Polyclonal
- Extra Details:
- Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7); a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase; leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop; leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1; when overexpressed; stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. Identification and characterization of lin-28 homolog B (LIN28B) in human hepatocellular carcinoma.""
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.242~246( P-S-V-Q-K) derived from Human LIN28B
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
