Polyclonal Antibody to FoxA2(HNF-KBeta)
Product Sizes
50 µl
£511.00
35-1777-50UL
100 µl
£581.00
35-1777-100UL
About this Product
- SKU:
- 35-1777
- Additional Names:
- HNF-KB|| TCF3B
- Clonality:
- Polyclonal
- Extra Details:
- Transcription factor that is involved in embryonic development; establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' . In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver; pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally discribed as a transcription activator for a number of liver genes such as AFP; albumin; tyrosine aminotransferase; PEPCK; etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.435~439( A-S-P-L-A) derived from Human FoxA2(HNF-KB).
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
