Polyclonal Antibody to Caspase8
Product Sizes
50 µl
£511.00
35-1675-50UL
100 µl
£581.00
35-1675-100UL
About this Product
- SKU:
- 35-1675
- Additional Names:
- ICE-like apoptotic protease 5
- Clonality:
- Polyclonal
- Extra Details:
- Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3; CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3; CASP4; CASP6; CASP7; CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate; Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5; isoform 6; isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.217~221 (S-E-S-Q-T) derived from Caspase 8.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
