Polyclonal Antibody to Shc1 (Ab-427)
Product Sizes
50 µl
£511.00
35-1638-50UL
100 µl
£581.00
35-1638-100UL
About this Product
- SKU:
- 35-1638
- Additional Names:
- SH2 domain protein C1|| SHC|| SHC-transforming protein 1|| SHCA|| Src homology 2 domain-containing-transforming protein C1
- Clonality:
- Polyclonal
- Extra Details:
- Signaling adapter that couples activated growth factor receptors to signaling pathway. Isoform p46Shc and isoform p52Shc; once phosphorylated; couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation; but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants; cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.425~429 (P-S-Y-V-N) derived from Human Shc1.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
