Polyclonal Antibody to Tyrosine Hydroxylase (Ab-31)
Product Sizes
50 µl
£511.00
35-1623-50UL
100 µl
£581.00
35-1623-100UL
About this Product
- SKU:
- 35-1623
- Additional Names:
- TYH|| DYT14|| DYT5b|| TH
- Clonality:
- Polyclonal
- Extra Details:
- Tyrosine hydroxylase (TH) catalyzes the rate-limiting step in the synthesis of the neurotransmitter dopamine and other catecholamines. TH functions as a tetramer; with each subunit composed of a regulatory and catalytic domain; and exists in several different isoforms . This enzyme is required for embryonic development since TH knockout mice die before or at birth . Levels of transcription; translation and posttranslational modification regulate TH activity. The amino-terminal regulatory domain contains three serine residues: Ser9; Ser31 and Ser40. Phosphorylation at Ser40 by PKA positively regulates the catalytic activity of TH . Phosphorylation at Ser31 by CDK5 also increases the catalytic activity of TH through stabilization of TH protein levels.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.29~33(V-T-S-P-R)derived from Mouse Tyrosine Hydroxylase.
- Isotype:
- Rabbit IgG
- Reactivities:
- Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
