Polyclonal Antibody to p70 S6 Kinase (Ab-424)
Product Sizes
50 µl
£511.00
35-1606-50UL
100 µl
£581.00
35-1606-100UL
About this Product
- SKU:
- 35-1606
- Additional Names:
- KS6B1|| P70-S6K|| RPS6KB1|| S6K
- Clonality:
- Polyclonal
- Extra Details:
- RPS6KB1 phosphorylates the Ribosomal Protein-S6. Activation of RPS6KB1 requires a complex; ordered series of conformational changes and phosphorylation reactions. While the role of sequential; multi-site phosphorylation has been extensively detailed; characterization of the priming step required to initiate this cascade has remained elusive. Probably this priming process is dependent on calcium. Calcium-dependent regulation of RPS6KB1 does not specifically target Thr-229 and Thr-389; the key regulatory phosphorylation sites; rather; calcium chelation results in a global inhibition of RPS6KB1 phosphorylation. The initial calcium-dependent process is required to release an inhibitory interaction between the C- and N-termini of RPS6KB1; thus allowing phosphorylation of key domains. The priming event involves formation of a calcium-dependent protein complex that releases the interaction between the N- and C-termini. RPS6KB1 is then accessible for activation by the kinases that target the known regulatory phosphorylation sites . Satoru Eguchi et al. (1999) J Biol Chem; Vol. 274: 36843-36851 Papst PJ; et al. (1998) J Biol Chem. 273(24):15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 c Le; X.F; et al. (2003) Oncogene 22: 484
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.422~426 (P-V-S-P-V) derived from Human p70S6k.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
