Polyclonal Antibody to Histone H2A.X (Ab-139)
Product Sizes
50 µl
£511.00
35-1593-50UL
100 µl
£581.00
35-1593-100UL
About this Product
- SKU:
- 35-1593
- Additional Names:
- H2A.X|| H2AFX|| H2a/x|| HIST5-2AX
- Clonality:
- Polyclonal
- Extra Details:
- Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin; limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation; DNA repair; DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones; also called histone code; and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.137~141 (Q-A-S-Q-E) derived from Human Histone H2A.X.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
