Polyclonal Antibody to Zap-70 (Ab-319)
Product Sizes
50 µl
£511.00
35-1515-50UL
100 µl
£581.00
35-1515-100UL
About this Product
- SKU:
- 35-1515
- Additional Names:
- 70 kDa zeta-associated protein|| SRK|| Syk-related tyrosine kinase|| ZA70|| ZAP-70
- Clonality:
- Polyclonal
- Extra Details:
- ZAP70 is a 70-kD tyrosine phosphoprotein that associates with the zeta chain and undergoes tyrosine phosphorylation following TCR stimulation. The ZAP70 gene is expressed in T- and natural KILLER cells. Protein-Tyrosine Kinases (PTKs) play an integral role in T-cell activation. Stimulation of the T-cell antigen receptor results in tyrosine phosphorylation of a number of cellular substrates. One of these is the TCR-zeta chain; which can mediate the transduction of extracellular stimuli into cellular effector functions Salomon AR; et al. (2003) Proc Natl Acad Sci U S A; 100(2): 443-448 Ku GM; et al. (2001) EMBO J; 20(3): 457-465 Tang J; et al. (1999) Proc Natl Acad Sci U S A; 96(17): 9775-9780 Zhao Q; et al. (1996) Mol Cell Biol; 16(12): 6765-6774 Williams BL; et al. (1999) EMBO J; 18(7): 1832-1844 Adjali O; et al. (2005) J Clin Invest; 115(8): 2287-2295.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.317~321 (S-P-Y-S-D) derived from Human ZAP70.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
