Polyclonal Antibody to MKK6 (Ab-207)
Product Sizes
50 µl
£511.00
35-1498-50UL
100 µl
£581.00
35-1498-100UL
About this Product
- SKU:
- 35-1498
- Additional Names:
- MAP kinase kinase 6|| MAP2K6|| MAPK/ERK kinase 6|| MAPKK 6|| MEK6
- Clonality:
- Polyclonal
- Extra Details:
- MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6; encodes a 278-amino acid protein; while the longer clone; designated MKK6b; encodes a 334-amino acid protein. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle; while an MKK6b-specific probe detected mRNA bands of 1.8; 2.4; and 4.5 kb that are enriched in heart; skeletal muscle; pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway; this gene is involved in many cellular processes such as stress induced cell cycle arrest; transcription activation and apoptosis. Wang W; et al. (2002) Mol Cell Biol ; 22(10): 3389-403. Raingeaud J; et al. (1996) Mol Cell Biol; 16(3): 1247-55.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.205~209 (V-D-S-V-A) derived from Human MKK6.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
