Polyclonal Antibody to HDAC5 (Ab-498)
Product Sizes
50 µl
£511.00
35-1490-50UL
100 µl
£581.00
35-1490-100UL
About this Product
- SKU:
- 35-1490
- Additional Names:
- HD5
- Clonality:
- Polyclonal
- Extra Details:
- Histones play a critical role in transcriptional regulation; cell cycle progression; and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by HDAC5 belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins; resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. Doppler H; et al. (2005) J Biol Chem. 280(15):15013-15019. McKinsey TA; et al. (2000) Nature. 408(6808): 106-111.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.496~500 (T-Q-S-S-P) derived from Human HDAC5/7.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
