Polyclonal Antibody to Androgen Receptor (Ab-650)
Product Sizes
50 µl
£511.00
35-1457-50UL
100 µl
£581.00
35-1457-100UL
About this Product
- SKU:
- 35-1457
- Additional Names:
- ANDR|| DHTR|| AR
- Clonality:
- Polyclonal
- Extra Details:
- The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain; DNA-binding domain; and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand; the receptor dissociates from accessory proteins; translocates into the nucleus; dimerizes; and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. Brinkman; A.O. et al. (1999) J. Steroid. Biochem. Mol. Biol. 69; 307-313. Avila; D.M. et al. (2001) J. Steroid. Biochem. Mol. Biol. 76; 135-142. Montgomery; J.S. et al. (2001) J. Pathol. 195; 138-146.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around aa.648~652 (T-T-S-P-T) derived from Human Androgen Receptor.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
