Polyclonal Antibody to eIF4G (phospho-Ser1231)
Product Sizes
50 µl
£511.00
35-1311-50UL
100 µl
£581.00
35-1311-100UL
About this Product
- SKU:
- 35-1311
- Clonality:
- Polyclonal
- Extra Details:
- eIF4F is a multi-subunit complex; the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A; EIF4E and EIF4G1/EIF4G3. Interacts with eIF3; mutually exclusive with EIF4A1 or EIFA2; EIF4E and through its N-terminus with PAPBC1. Interacts through its C-terminus with the serine/threonine kinases MKNK1; and with MKNK2. Appears to act as a scaffold protein; holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation. EIF4G1/EIF4G3 interacts with PABPC1 to bring about circularization of the mRNA. Rapamycin can attenuate insulin stimulation mediated by FKBPs. Interacts with EIF4E3. Interacts with MIF4GD. Interacts with rotavirus A NSP3; in this interaction; NSP3 takes the place of PABPC1 thereby inducing shutoff of host protein synthesis De Gregorio; E. et al. (1998) RNA 4; 828-836. Ohlmann; T. et al. (1996) EMBO J. 15; 1371-1382. Borman; A.M. and Kean; K.M. (1997) Virology 237; 129-136. Gradi; A. et al. (1998) Mol Cell Biol 18; 334-42.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 1231 (P-V-S(p)-P-L) derived from Human eIF4G.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
