Polyclonal Antibody to JNK1/JNK2/JNK3 (phospho-Thr183/Tyr185)
Product Sizes
50 µl
£594.00
35-1303-50UL
100 µl
£724.00
35-1303-100UL
About this Product
- SKU:
- 35-1303
- Additional Names:
- Stress-activated protein kinase JNK1|| c-Jun N-terminal kinase 1|| JNK-46
- Clonality:
- Polyclonal
- Extra Details:
- Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors; primarily components of AP-1 such as JUN; JDP2 and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells; JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors; primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. In T-cells; JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: a-1 and a-2 preferentially bind to c-Jun; whereas beta-1 and beta-2 bind to ATF2. However; there is no correlation between binding and phosphorylation; which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 a-2; and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors; primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptional activity. Required for stress-induced neuronal apoptosis and the pathogenesis of glutamate excitotoxicity Davis; R.J. (1999) Biochem Soc Symp 64; 1-12. Ichijo; H. (1999) Oncogene 18; 6087-93. Kyriakis; J.M. and Avruch; J. (2001) Physiol Rev 81; 807-69.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of Thr183/Tyr185 (M-M-T(p)-P-Y(p)- V - V ) derived from Human JNK1/JNK2/JNK3.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
