Polyclonal Antibody to CARM1(Phospho-Ser228)
Product Sizes
50 µl
£511.00
35-1298-50UL
100 µl
£581.00
35-1298-100UL
About this Product
- SKU:
- 35-1298
- Additional Names:
- PRMT4
- Clonality:
- Polyclonal
- Extra Details:
- Methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging; transcription regulation; pre-mRNA splicing; and mRNA stability. Recruited to promoters upon gene activation together with histone acetyltransferases from EP300/P300 and p160 families; methylates histone H3 at 'Arg-17' (H3R17me); forming mainly asymmetric dimethylarginine (H3R17me2a); leading to activate transcription via chromatin remodeling. During nuclear hormone receptor activation and TCF7L2/TCF4 activation; acts synergically with EP300/P300 and either one of the p160 histone acetyltransferases NCOA1/SRC1; NCOA2/GRIP1 and NCOA3/ACTR or CTNNB1/beta-catenin to activate transcription. During myogenic transcriptional activation; acts together with NCOA3/ACTR as a coactivator for MEF2C. During monocyte inflammatory stimulation; acts together with EP300/P300 as a coactivator for NF-kappa-B. Acts as coactivator for PPARG; promotes adipocyte differentiation and the accumulation of brown fat tissue. Plays a role in the regulation of pre-mRNA alternative splicing by methylation of splicing factors. Also seems to be involved in p53/TP53 transcriptional activation. Methylates EP300/P300; both at 'Arg-2142'; which may loosen its interaction with NCOA2/GRIP1; and at 'Arg-580' and 'Arg-604' in the KIX domain; which impairs its interaction with CREB and inhibits CREB-dependent transcriptional activation. Also methylates arginine residues in RNA-binding proteins PABPC1; ELAVL1 and ELAV4; which may affect their mRNA-stabilizing properties and the half-life of their target mRNAs
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 228(V-K-S(p)-N-N) derived from Human CARM1.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
