Polyclonal Antibody to IKK-beta(Phospho-Tyr199)
Product Sizes
50 µl
£511.00
35-1275-50UL
100 µl
£581.00
35-1275-100UL
About this Product
- SKU:
- 35-1275
- Additional Names:
- IKK2|| IKKB|| NF-KBIKB|| IKK-beta
- Clonality:
- Polyclonal
- Extra Details:
- Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines; bacterial or viral products; DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn; free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response; growth control; or protection against apoptosis. In addition to the NF-kappa-B inhibitors; phosphorylates several other components of the signaling pathway including NEMO/IKBKG; NF-kappa-B subunits RELA and NF-KB1; as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Also phosphorylates other substrates including NCOA3; BCL10 and IRS1. Within the nucleus; acts as an adapter protein for NF-KBIA degradation in UV-induced NF-kappa-B activation.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of tyrosine 199(Q-K-Y(p)-T-V)derived from Human IKK-B.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
