Polyclonal Antibody to IGF-1R (Phospho-Tyr1280)
Product Sizes
50 µl
£511.00
35-1273-50UL
100 µl
£581.00
35-1273-100UL
About this Product
- SKU:
- 35-1273
- Additional Names:
- IGFR|| CD221|| IGFIR
- Clonality:
- Polyclonal
- Extra Details:
- This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity; which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR; binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1; with low affinity by IGF2 and not significantly activated by insulin; and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1; IGF2 and insulin. In contrast; Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics; both bind IGF1 and have a low affinity for insulin. Adams; T.E. et al. (2000) Cell. Mol. Life Sci. 57; 1050-1093 Baserga; R. et al. (2000) Oncogene 19; 5574-5581 Scheidegger; K.J. et al. (2000) J. Biol. Chem. 275; 38921-38928. O'Connor R; et al. Mol Cell Biol 1997 Jan; 17(1): 427-35
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y(p)-Y-S) derived from Human IGF-1R
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
