Polyclonal Antibody to Integrin beta3 (Phospho-Tyr785)
Product Sizes
50 µl
£511.00
35-1258-50UL
100 µl
£581.00
35-1258-100UL
About this Product
- SKU:
- 35-1258
- Additional Names:
- CD61 antigen|| GP3A|| GPIIIa|| ITB3|| Platelet membrane glycoprotein IIIa
- Clonality:
- Polyclonal
- Extra Details:
- Integrin a-V/beta-3 is a receptor for cytotactin; fibronectin; laminin; matrix metalloproteinase-2; osteopontin; osteomodulin; prothrombin; thrombospondin; vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin; fibrinogen; plasminogen; prothrombin; thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection; the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of tyrosine 785 (I-T-Y(p)-R-G) derived from Human Integrin b3.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
