Polyclonal Antibody to Cortactin (Phospho-Tyr466)
Product Sizes
50 µl
£511.00
35-1250-50UL
100 µl
£581.00
35-1250-100UL
About this Product
- SKU:
- 35-1250
- Additional Names:
- Amplaxin|| CTTN|| EMS1|| SRC8
- Clonality:
- Polyclonal
- Extra Details:
- Cortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis; the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene. Luo C; et al. (2006) J Biol Chem ; 281(40):30081-30093 Head JA; et al. (2003) Mol Biol Cell ;14(8):3216-3229 Li Y; et al. (2000) J Biol Chem ; 275(47): 37187-37193 Kinley AW; et al. (2003) Curr Biol ; 13(5): 384-393
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of tyrosine 466 (P-V-Y(p)-E-T) derived from Human CORTACTIN.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
