Polyclonal Antibody to PKCbeta (Phospho-Thr641)
Product Sizes
50 µl
£511.00
35-1163-50UL
100 µl
£581.00
35-1163-100UL
About this Product
- SKU:
- 35-1163
- Additional Names:
- PKCB|| PRKCB1|| PRKCB2
- Clonality:
- Polyclonal
- Extra Details:
- Calcium-activated and phospholipid-dependent serine/threonine-protein kinase involved in various processes such as regulation of the B-cell receptor (BCR) signalosome; apoptosis and transcription regulation. Plays a key role in B-cell activation and function by regulating BCR-induced NF-kappa-B activation and B-cell suvival. Required for recruitment and activation of the IKK kinase to lipid rafts and mediates phosphorylation of CARD11/CARMA1 at 'Ser-559'; 'Ser-644' and 'Ser-652'; leading to activate the NF-kappa-B signaling. Involved in apoptosis following oxidative damage: in case of oxidative conditions; specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1; leading to mitochondrial accumulation of p66Shc; where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription; by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph); a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. Also involved in triglyceride homeostasis. Serves as the receptor for phorbol esters; a class of tumor promoters. Zhang Y; et al. (2006) Mol Cell Biol ; 26: 6748-6761 Castoria G; et al. (2004) Mol Cell Biol ; 24: 7643-7653 Marcil J; et al. (1999) Biochem J ; 337:185-192 Bornancin F; et al. (1996) Curr Biol ; 6:1114-1123.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKCb
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
