Polyclonal Antibody to PAK1/PAK2/PAK3 (Phospho-Thr423/Thr402/Thr421)

Product Sizes

50 µl

£511.00

35-1158-50UL

100 µl

£581.00

35-1158-100UL

About this Product

SKU:: 35-1158
Additional Names:: p21-activated kinase 1|| PAK-1|| p65-PAK|| Alpha-PAK
Clonality:: Polyclonal
Extra Details:: The activated kinase acts on a variety of targets. Likely to be the GTPase effector that links the Rho-related GTPases to the JNK MAP kinase pathway. Activated by CDC42 and RAC1. Involved in dissolution of stress fibers and reorganization of focal complexes. Involved in regulation of microtubule biogenesis through phosphorylation of TBCB. Activity is inhibited in cells undergoing apoptosis; potentially due to binding of CDC2L1 and CDC2L2. Parsons M; et al. (2005) Mol Cell Biol ; 25:1680-1695. Jung JH; et al. (2005) J Biol Chem; 280:40025-40031. Lampugnani MG; et al. (2002) Mol Biol Cell ; 13: 1175-1189 Wang RA; et al. (2002) EMBO J; 21: 5437 - 5447.
Format:: Purified
Host:: Rabbit
Immunogen:: Peptide sequence around phosphorylation site of threonine 423 /402/421 (R-S-T(p)-M-V) derived from Human PAK1/PAK2/PAK3.
Isotype:: Rabbit IgG
Reactivities:: Human, Mouse, Rat
Shipping Conditions:: Blue Ice
Storage Conditions:: Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
Supplier:: Abeomics
Type:: Antibodies:Polyclonal Antibody

Basket