Polyclonal Antibody to STAT1 (Phospho-Ser727)
Product Sizes
50 µl
£511.00
35-1156-50UL
100 µl
£581.00
35-1156-100UL
About this Product
- SKU:
- 35-1156
- Additional Names:
- ISGF-3|| STAT9
- Clonality:
- Polyclonal
- Extra Details:
- Signal transducer and activator of transcription that mediates signaling by interferons (IFNs). Following type I IFN (IFN-a and IFN-beta) binding to cell surface receptors; Jak kinases (TYK2 and JAK1) are activated; leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize; associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor; that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes; which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma); STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF); migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes; inducing a cellular antiviral state.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 727 (P-M-S(p)-P-E) derived from Human STAT1.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
