Polyclonal Antibody to ATM (Phospho-Ser1981)
Product Sizes
50 µl
£511.00
35-1118-50UL
100 µl
£581.00
35-1118-100UL
About this Product
- SKU:
- 35-1118
- Additional Names:
- Ataxia telangiectasia mutated homolog|| Ataxia telangiectasia mutated|| kinase ATM
- Clonality:
- Polyclonal
- Extra Details:
- ATM encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus; it functions as a regulator of a wide variety of downstream proteins; including tumor suppressor proteins p53 and BRCA1; checkpoint kinase CHK2; checkpoint proteins RAD17 and RAD9; and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia; an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. Gupta A. et al. (2005) Mol Cell Biol. 25(12): 5292-5305. Bernstein JL. et al. (2002) Breast Cancer Res. 4(6): 249-252. Silverman J. et al. (2004) Genes Dev. 18(17): 2108-2119. Nakada D. et al. (2003) Nucleic Acids Res. 31(6): 1715-1724.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 1981 (E-G-S(p)-Q-S) derived from Human ATM.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
