Polyclonal Antibody to CREB (Phospho-Ser133)
Product Sizes
50 µl
£511.00
35-1051-50UL
100 µl
£581.00
35-1051-100UL
About this Product
- SKU:
- 35-1051
- Additional Names:
- CREB-1|| CREB1
- Clonality:
- Polyclonal
- Extra Details:
- CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element); an octameric palindrome containing a conserved core sequence; 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories; but not for encoding; storage; or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories . Xing J; et al. (1998) Mol Cell Biol 18(4): 1946-55. Tan Y; et al. (1996) EMBO J; 15(17): 4629-42. Hao; M. et al. (1996) J. Biol. Chem. 271; 29380-29385. Mayo LD; et al. (2001) Biol Chem; 276(27): 25184-9.
- Format:
- Purified
- Host:
- Rabbit
- Immunogen:
- Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R) derived from Human CREB.
- Isotype:
- Rabbit IgG
- Reactivities:
- Human, Mouse, Rat
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store the antibody at 4[o]C; stable for 6 months. For long-term storage; store at -20[o]C. Avoid repeated freeze and thaw cycles.
- Supplier:
- Abeomics
- Type:
- Antibodies:Polyclonal Antibody
- Manufacturer's Data Sheet:1.jpg
