Recombinant Mouse Death Receptor 6/DR6/TNFRSF21/CD358 (C-Fc-6His)
Product Sizes
50 µg
£656.00
32-9725-50UG
500 µg
£1959.00
32-9725-500UG
About this Product
- SKU:
- 32-9725
- Additional Names:
- Tumor necrosis factor receptor superfamily member 21;Death receptor 6;Tnfrsf21;CD358;BM-018;DR6
- Extra Details:
- Source : Human Cells;Tumor necrosis factor receptor superfamily member 21(DR6) is a single-pass type I membrane protein and contains 1 death domain and 4 TNFR-Cys repeats. The protein may activate NF-kappa-B and promote apoptosis and it may activate JNK and be involved in T-cell differentiation.It is required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
