Recombinant Human Interferon alpha/beta Receptor 2/IFNAR2 (C-Fc)
Product Sizes
50 µg
£656.00
32-9660-50UG
500 µg
£1959.00
32-9660-500UG
About this Product
- SKU:
- 32-9660
- Additional Names:
- Interferon Alpha/Beta Receptor 2; IFN-R-2; IFN-Alpha Binding Protein; IFN-Alpha/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2; IFNABR; IFNARB
- Extra Details:
- Source : Human Cells;Interferon -Alpha/Beta Receptor 2 (IFN--Alpha/Beta R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN--Alpha/Beta R1 to form the signaling receptor complex for the family of -Alpha and Beta IFN subtypes. By alternative splicing; IFN--Alpha/Beta R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN--Alpha/Beta R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN--Alpha/Beta R1; resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes; monocytes; and granulocytes; although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets; IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase; JAK1. Isoform 1 also interacts with the transcriptional factors; STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
