Recombinant Human TIGIT/VSIG9/VSTM3 (C-mFC)
Product Sizes
50 µg
£625.00
32-9639-50UG
500 µg
£1959.00
32-9639-500UG
About this Product
- SKU:
- 32-9639
- Additional Names:
- T-cell immunoreceptor with Ig and ITIM domains;;VSIG9; VSTM3;TIGIT;V-set and transmembrane domain-containing protein 3;V-set and immunoglobulin domain-containing protein 9
- Extra Details:
- Source : Human Cells;T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a member of the CD28 family within the Ig superfamily of proteins. TIGIT is expressed on NK cells and subsets of activated; memory and regulatory T cells; and particularly on follicular helper T cells within secondary lymphoid organs. It binds to CD155 and Nectin-2 that appear on dendritic cells (DC) and endothelium. Ligation of TIGIT on T cells down-regulates TCR-mediated activation and subsequent proliferation; while NK cell TIGIT ligation blocks NK cell cytotoxicity. Through CD155 and Nectin-2; which also interact with DNAM-1/CD226 and CD96/Tactile; TIGIT is part of an interacting network of Ig superfamily members that may augment or oppose each other. In particular; TIGIT binding to CD155 can antagonize the effects of DNAM1.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
