Recombinant Cynomolgus TIGIT/VSIG9/VSTM3 (C-FC)
Product Sizes
50 µg
£801.00
32-9638-50UG
500 µg
£1995.00
32-9638-500UG
About this Product
- SKU:
- 32-9638
- Additional Names:
- T-cell immunoreceptor with Ig and ITIM domains; VSIG9; VSTM3; TIGIT; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9
- Extra Details:
- Source : Human Cells;T cell immunoreceptor with Ig and ITIM domains (TIGIT); also called VSIG9 and Vstm3; is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain; a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM); and is expressed on regulatory; memory; activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells (DC); macrophages and endothelium with high affinity; and CD112(PVRL2) with lower affinity; but not CD113 (PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10; but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges; while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
