Recombinant Human Tumor Necrosis Factor Ligand/TNFSF13/APRIL (N-Flag-His)
Product Sizes
50 µg
£631.00
32-9621-50UG
500 µg
£2272.00
32-9621-500UG
About this Product
- SKU:
- 32-9621
- Additional Names:
- Tumor necrosis factor ligand superfamily member 13; A proliferation-inducing ligand; APRIL; TNF- and APOL-related leukocyte expressed ligand 2; TALL-2; TNF-related death ligand 1; TRDL-1; CD256; TNFSF13
- Extra Details:
- Source : Human Cells;APRIL(a proliferation-inducing ligand); also known as TNFSF13; TALL2; TRDL1; and CD256; is a member of the TNF ligand superfamily. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. Secreted human APRIL; which consists almost entirely of a single TNF homology domain; shares 85% amino acid sequence identity with mouse and rat APRIL. Both APRIL and its close relative BAFF bind and signal through the TNF superfamily receptors TACI and BCMA; while BAFF additionally functions through BAFF R. APRIL binds to heparan sulfate proteoglycans (HSPGs) independently of its binding to TACI and BCMA. APRIL can form bioactive heterotrimers with BAFF; and these circulate in the serum of patients with rheumatic immune disorders. APRIL enhances the proliferation and survival of plasma cells and also promotes T cell-dependent humoral responses. APRIL levels are elevated in the serum during coronary artery disease; and it is also elevated in many cancers primarily due to expression by tumor-infiltrating neutrophils.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
