Recombinant Cynomolgus TIM-3/HAVCR2 (N-His)
Product Sizes
50 µg
£656.00
32-9616-50UG
500 µg
£1534.00
32-9616-500UG
About this Product
- SKU:
- 32-9616
- Additional Names:
- T cell immunoglobulin and mucin domain3; HAVCR2; Tim-3; TIM3
- Extra Details:
- Source : Human Cells;T cell immunoglobulin and mucin domain 3 is a member of the TIM family of immune regulating molecules. Mature cynomolgus TIM3 consists of a 182 amino acid (aa)extracellular domain (ECD); a 21 aa transmembrane segment; and a 78 aa cytoplasmic tail. TIM3 is up-regulated on several populations of activated myeloid cells (macrophage; monocyte; dendritic cell; microglia; mast cell) and T cells (Th1; CD8+; NK; Treg). Its binding to Galectin9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. TIM3 ligation attenuates CD8+ and Th1 cell responses and promotes the activity of Treg and myeloid derived suppressor cells. TIM3 interactions with Galectin-9 can trigger immune stimulatory effects; such as the coactivation of NK cell cytotoxicity.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
