Recombinant 2019-nCoV Helicase (N-6His-MBP)
Product Sizes
50 µg
£756.00
32-9556-50UG
500 µg
£2070.00
32-9556-500UG
About this Product
- SKU:
- 32-9556
- Additional Names:
- SARS-CoV 2 Helicase; SARS-CoV 2 nsp13
- Extra Details:
- Source : E. coli;The non-structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double-stranded RNA or DNA with a 5'-3' polarity; using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction; and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nucleic acids into two single-stranded nucleic acids. Initially; helicases were only thought to be molecular engines that unwind nucleic acids during replication; recombination; and DNA repair. Recent studies have shown that they are also involved in other biological processes; including displacement of proteins from nucleic acid; movement of Holliday junctions; chromatin remodeling; catalysis of nucleic acid conformational changes; several aspects of RNA metabolism; including transcription; mRNA splicing; mRNA export; translation; RNA stability and mitochondrial gene expression. Some human diseases; including Bloom ’ s syndrome; Werner ’ s syndrome; and Xeroderma Pigmentosum have been associated with defects in helicase function.
- Shipping Conditions:
- Dry Ice
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
