Recombinant Rat Tumor Necrosis Factor/TNF-alpha
Product Sizes
50 µg
£722.00
32-9537-50UG
500 µg
£1959.00
32-9537-500UG
About this Product
- SKU:
- 32-9537
- Additional Names:
- Tumor Necrosis Factor; Cachectin; TNF-Alpha; Tumor Necrosis Factor Ligand Superfamily Member 2; TNF-a; Tumor Necrosis Factor; Membrane Form; Tumor Necrosis Factor; Soluble Form; Tnf; Tnfa; Tnfsf2
- Extra Details:
- Source : E. coli;Tumor necrosis factor alpha (TNF-alpha; TNFSF2) is the prototypic ligand of the TNF superfamily. Rat TNF-alpha consisits of a 35 amino acid (aa) cytoplasmic domain; a 21 aa transmembrane segment; and a 179 aa extracellular domain (ECD). Within the ECD; rat TNF-alpha shares 94% aa sequence identity with mouse. TNF-alpha is produced by a wide variety of immune; epithelial; endothelial; and tumor cells. TNF exists as a homotrimer and interacts with SPPL2B. TNF is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. TNF is a key cytokine in the development of several inflammatory disorders. It contributes to the development of type 2 diabetes throught its effects on insulin resistance and fatty acid metabolism.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
