Recombinant Cynomolgus CD80/B7-1 (C-Fc)
Product Sizes
50 µg
£576.00
32-9519-50UG
500 µg
£1817.00
32-9519-500UG
About this Product
- SKU:
- 32-9519
- Additional Names:
- T-lymphocyte activation antigen CD80; Activation B7-1 antigen; B7; CD80
- Extra Details:
- Source : Human Cells;Cynomologous Cluster of Differentiation 80; also called B7-1; is a member of cell surface immunoglobulin superfamily.It is expressed on the surface of antigen-presenting cells including activated B cells; macrophages and dendritic cells.CD80 plays key; yet distinct roles in the activation of T cells. B7-1/CD80 and B7-2/CD86; together with their receptors CD28 and CTLA4; constitute one of the dominant co-stimulatory pathways that regulate T- and B- cell responses. CD80 is mostly expressed on the surface of antigen-presenting cells including activated B cells; macrophages and dendritic cells. Although both CTLA-4 and CD28 can bind to the same ligands; CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the down-regulation of the immune response. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
