Recombinant Human ALPL (C-His)
Product Sizes
50 µg
£897.00
32-9282-50UG
500 µg
£2009.00
32-9282-500UG
About this Product
- SKU:
- 32-9282
- Additional Names:
- Alkaline Phosphatase; Tissue-Nonspecific Isozyme; AP-TNAP; TNSALP; Alkaline Phosphatase Liver/Bone/Kidney Isozyme; ALPL
- Extra Details:
- Source : Human Cells;Alkaline Phosphatase; Tissue-Nonspecific Isozyme (ALPL) is a cell membrane protein which belongs to the alkaline phosphatase family. There are at least four distinct but related alkaline phosphatases in humans: intestinal AP (IAP); placental AP(PLAP); germ cell AP (GCAP) and their genes are clustered on chromosome 2; tissue-nonspecific isozyme (TNAP) which gene is located on chromosome 1. Alkaline phosphatases (APs) are dimeric enzymes; it catalyze the hydrolysis of phosphomonoesters with release of inorganic phosphate. The native ALPL is a glycosylated homodimer attached to the membrane through a GPI-anchor. This isozyme may play a role in skeletal mineralization. Mutations in ALPL gene have been linked directly to different forms of hypophosphatasia;characterized by poorly mineralized cartilage and bones; and this disorder can vary depending on the specific mutation since this determines age of onset and severity of symptoms.
- Purification:
- Greater than 95% as determined by reducing SDS-PAGE.
- Shipping Conditions:
- Dry Ice
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
