Recombinant Human CD3E (C-His)
Product Sizes
50 µg
£722.00
32-9160-50UG
500 µg
£1959.00
32-9160-500UG
About this Product
- SKU:
- 32-9160
- Additional Names:
- T-Cell Surface Glycoprotein CD3 Epsilon Chain; T-Cell Surface Antigen T3/Leu-4 Epsilon Chain;CD3e; CD3E; T3E
- Extra Details:
- Source : Human 293 Cells;CD3 epsilon (T-Cell Surface Glycoprotein CD3 Epsilon) is a type I transmembrane protein that belongs to the immunoglobulin superfamily. There are four CD3 proteins: CD3 delta; CD3 epsilon; CD3 gamma; and CD3 zeta. All CD3 proteins contain ITAM (Immunoreceptor Tyrosine-based Activation Motifs) in the cytoplasmic tail; which becomes phosphorylated by Src family protein tyrosine kinases LCK and FYN upon TCR engagement. CD3 proteins form heterodimers of CD3 delta/CD3 epsilon and CD3 gamma /CD3 epsilon; which bind to TCR and form trimeric TCR alpha /CD3 epsilon /CD3 gamma and TCR beta /CD3 gamma /CD3 epsilon. The resulting heterohexamer further associates with CD3 zeta homodimer and forms TCR/CD3 signaling complex. This complex is involved in coupling antigen recognition to several intracellular signal-transduction pathways. CD3 epsilon plays a critical role in adaptive immune response. Defects in CD3 epsilon lead to SCID (severe combined immunodeficiency).
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
