Recombinant Human Interleukin-12 Subunit Beta/IL-12B (C-His)
Product Sizes
50 µg
£722.00
32-9109-50UG
500 µg
£1959.00
32-9109-500UG
About this Product
- SKU:
- 32-9109
- Additional Names:
- IL12B; CLMF; CLMF2; NKSF; NKSF2; p40
- Extra Details:
- Source : Human 293 Cells;Interleukin-12 (IL-12) is a heterodimeric pleiotropic cytokine that consists of IL12A (p35) and IL12B (p40) subunits. IL 12 is expressed by macrophages and B lymphocytes and act as a growth factor for activated T and NK cells; help enhance the lytic activity of NK/lymphokine-activated killer cells; and stimulate the production of IFN-gamma by resting PBMC. Studies have shown that IL 12 is a key mediator of cellular-immunity and induces the differentiation of Th1 cells from precursor T helper cells. Based on its activities; it has been predicted that IL 12 may have therapeutic potential as a vaccine adjuvant that promotes cellular-immunity and as an anti-tumor and anti-viral agent. Interleukin-12 subunit beta (IL12B) has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12; and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis.
- Shipping Conditions:
- Ambient
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
