Recombinant Human Cellular Tumor Antigen p53 (N-His)
Product Sizes
50 µg
£772.00
32-9075-50UG
500 µg
£1726.00
32-9075-500UG
About this Product
- SKU:
- 32-9075
- Additional Names:
- Antigen NY-CO-13; BCC7; FLJ92943; LFS1; LFS1TRP53; p53 tumor suppressor; p53; P53cellular tumor antigen p53; Phosphoprotein p53; TP53; transformation-related protein 53; TRP53; tumor protein p53; Tumor suppressor p53
- Extra Details:
- Source : E. coli;p53 is a DNA-binding protein that belongs to the p53 family. p53 is expressed ubiquitously and its isoforms are expressed widely in normal tissues but in a tissue-dependent manner. It is well known for its key role as a tumor suppressor protein. p53 induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is also involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Whilst the activation of p53 often leads to apoptosis; p53 inactivation facilitates tumor progression. Mutants of p53; which frequently occur in different human cancers; fail to bind the consensus DNA binding site; and thus cause the loss of tumor suppressor activity. Defects in TP53 are a cause of esophageal cancer; Li-Fraumeni syndrome; lung cancer and adrenocortical carcinoma.
- Shipping Conditions:
- Dry Ice
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
