Recombinant Human Butyrophilin Subfamily 2 Member A2/BTN2A2 (C-Fc)
Product Sizes
10 µg
£554.00
32-9024-10UG
50 µg
£847.00
32-9024-50UG
About this Product
- SKU:
- 32-9024
- Extra Details:
- Source: Human Cells. MW :49.7kD. Recombinant Human Butyrophilin Subfamily 2 Member A2 is produced by our expression system and the target gene encoding Gln33-Val237 is expressed Butyrophilin 2A2 (BTN2A2) is a widely expressed type I transmembrane glycoprotein that functions as a negative regulator of immune responses. Mature human Butyrophilin 2A2 consisits of a 233 amino acid (aa) extracellular domain with two immunoglobulin-like domains; a 21 aa transmembrane segment; and a 237 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A2 that lack the first; second; or both Iglike domains as well as isoforms with substitutions and deletions in the cytoplasmic region. Within the immune system; Butyrophilin 2A2 is expressed on thymic epithelial cells; naïve B cells; splenic NK cells; dendritic cells; and peritoneal macrophages and is up-regulated with cell activation. Butyrophilin 2A2 inhibits T cell proliferation and activation and enhances the development of FoxP3+ regulatory T cells. Its up-regulation in the hippocampus is associated with schizophrenia.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
