Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 11B/Osteoprotegerin/TNFRSF11B (C-10His)
Product Sizes
10 µg
£493.00
32-9000-10UG
50 µg
£656.00
32-9000-50UG
About this Product
- SKU:
- 32-9000
- Extra Details:
- Source: Human Cells. MW :45.1kD. Recombinant Mouse Tumor Necrosis Factor Receptor Superfamily Member 11B is produced by our Mammalian expression system and the target gene encoding Glu22-Leu401 is expressed with a 10His tag at the C-terminus. Osteoprotegerin (OPG; Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells; fibroblasts and endothelial cells. Regulation of its expression by estrogen; parathyroid hormone and cytokines is complex and changes with age. OPG acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. TRAIL decreases the release of OPG from cells that express it; while OPG inhibits TRAIL-induced apoptosis. Expression of RANK L on the cell surface; and thus its ability to stimulate osteoclastogenesis; is regulated by OPG by intracellular and extracellular mechanisms. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. It may also play a role in preventing arterial calcification.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
