Recombinant Human Leptin Receptor/LEPR/CD295 (C-10His)
Product Sizes
10 µg
£474.00
32-8994-10UG
50 µg
£554.00
32-8994-50UG
About this Product
- SKU:
- 32-8994
- Extra Details:
- Source: Human Cells. MW :94.9kD. Recombinant Human Leptin Receptor is produced by our Mammalian expression system and the target gene encoding Phe22-Asp839 is expressed with a 10His tag at the C-terminus. The Leptin receptor is a member of the Class I cytokine receptor family. It mediates the activities of Leptin; a multi-functional hormone produced primarily by adipose tissues that plays roles in food intake; energy metabolism; angiogenesis; reproduction; hematopoiesis; bone metabolism; and immune function. The human Leptin R gene encodes 1165 amino acids (aa) including a signal peptide; an extracellular region with cytokine receptor homology (CRH); multiple fibronectin type III domains and a WSXWS motif; a transmembrane domain; and a cytoplasmic domain that supports JAK/STAT signaling. Soluble Leptin R is the primary Leptin-binding protein in blood; where it maintains a pool of available bioactive Leptin; delays Leptin clearance from circulation; and down-regulates blood-brain transmission of Leptin. In humans; soluble Leptin R levels are inversely proportional to adiposity and are elevated in females versus males. Soluble Leptin R is also found up-regulated in patients with chronic heart failure; end-stage renal disease; and anorexia.It is expressed by tumor-initiating stem cells; and is proposed as a link between cancer and obesity.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
