Recombinant Mouse Sclerostin/SOST (C-6His)
Product Sizes
10 µg
£554.00
32-8961-10UG
50 µg
£847.00
32-8961-50UG
About this Product
- SKU:
- 32-8961
- Extra Details:
- Source: Human Cells. MW :21.9kD. Recombinant Mouse Sclerostin is produced by our Mammalian expression system and the target gene encoding Gln24-Tyr211 is expressed with a 6His tag at the C-terminus. Sclerostin (SOST) is a member of the cerberus/DAN family; a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists; and include Dan; Cerberus; Gremlin; PRDC; and Caronte. While the overall sequence identity between members of the family is low; they have conserved spacing of six cysteine residues. Cerberus and Dan have an additional cysteine residue used for dimerization; however; SOST does not and is secreted as a monomer. SOST was originally identified as an important regulator of bone homeostasis. SOST is expressed by osteoclasts in developing bones of mouse embryos; including both intramembranously forming skull bones and endochondrally forming long bones. SOST plays a physiological role as a negative regulator of bone formation by repressing BMP-induced osteogenesis. SOST has been shown to have unique ligand specificity; binding BMP-5; -6; and -7 with high affinity and BMP-2 and -4 with low affinity.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
