Recombinant Human CD166 Antigen (C-Fc)
Product Sizes
10 µg
£433.00
32-8934-10UG
50 µg
£493.00
32-8934-50UG
About this Product
- SKU:
- 32-8934
- Extra Details:
- Source: Human cells. MW :82.7kD. Recombinant Human CD166 Antigen is produced by our Mammalian expression system and the target gene encoding Trp28-Ala526 is expressed with a Fc tag at the C-terminus. Activated leukocyte cell adhesion molecule (ALCAM); also named as CD166 and MEMD; is a typeI transmembrane glycoprotein of immunoglobulin superfamily; which mediates homotypic and heterotypic interactions between cells. ALCAM is expressed on thymic epithelium; microvascular endothelium; activated lymphocytes and monocytes; and monocytederived dendritic cells. ALCAM mediates low-affinity adhesion with itself or the cysteine-rich scavenger receptor CD6 to regulate T cell development; immunological synapses(IS); and cell migration through endothelial junctions. ALCAM on thymic epithelia mediates adhesion to CD6 on CD4+CD8+ T cells. Adhesion of ALCAM expressing antigen presenting cells and CD6-expressing T cells stabilizes the early IS; while later it enhances CD3 effects on T cell proliferation; CD25 expression; and Th1 commitment. ALCAM may influence expression or adhesion of the neuronal adhesion molecule NCAML1; both in the developing retina and invasive melanoma.
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
