Recombinant Mouse C-C motif chemokine 2/CCL2 (C-6His)
Product Sizes
10 µg
£604.00
32-8902-10UG
50 µg
£897.00
32-8902-50UG
About this Product
- SKU:
- 32-8902
- Extra Details:
- Source: Human cells. MW :14.7kD. Recombinant Mouse C-C motif chemokine 2 is produced by our Mammalian expression system and the target gene encoding Gln24-Asn148 is expressed with a 6His tag at the C-terminus. C-C motif chemokine 2 (CCL2) is a member of the C-C or beta chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence; and 58%; 56%; 55%; 53% and 53% aa identity with human; equine; porcine; bovine and canine CCL2; respectively. Fibroblasts; glioma cells; smooth muscle cells; endothelial cells; lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation; but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity; CCL2 induces enzyme and cytokine release by monocytes; NK cells and lymphocytes; and histamine release by basophils that express its receptor; CCR2. Additionally; it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis; multiple sclerosis and allergic asthma.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Store at -20[o]C; stable for 6 months after receipt. Please minimize freeze-thaw cycles.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
