Recombinant Mouse ICOS Ligand/B7-H2/CD275 (C-6His)
Product Sizes
10 µg
£549.00
32-8894-10UG
50 µg
£706.00
32-8894-50UG
About this Product
- SKU:
- 32-8894
- Extra Details:
- Source: Human Cells. MW :27.1kD. Recombinant Mouse ICOS Ligand is produced by our Mammalian expression system and the target gene encoding Glu47-Lys279 is expressed fused with a 6His tag at the C-terminus. Mouse ICOS ligand(B7-H2) is an approximately transmembrane glycoprotein in the B7 family of immune regulatory molecules. B7-H2 is expressed on antigen presenting cells such as B cells; macrophages; monocytes; and dendritic cells. It binds to ICOS on activated T cells; leading to both positive and negative effects on immune responses including its own down-regulation. The B7-H2 interaction with ICOS is costimulatory for T cell proliferation as well as the development of B cells; plasma cells; follicular helper T cells and germinal centers. B7-H2 contributes to the development of allergic asthma by enhancing Th2 biased immune responses; limiting Th17 responses; and promoting eosinophilic infiltration into the lung. Its activation of ICOS on Treg limits pulmonary inflammation and airway hyperresponsiveness; promotes the development of inhalational tolerance; and impairs antitumor immunity. In the thyroid; B7-H2 is up-regulated on thyrocytes during inflammation and promotes their proliferation and production of thryoid hormones.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
