Recombinant Human Interleukin-10 Receptor Subunit Alpha/IL-10 Ra (C-6His)
Product Sizes
10 µg
£502.00
32-8845-10UG
50 µg
£781.00
32-8845-50UG
About this Product
- SKU:
- 32-8845
- Extra Details:
- Source: E. coli. MW :25.2kD. Recombinant Human Interleukin-10 Receptor Subunit Alpha is produced by our E. coli expression system and the target gene encoding His22-Asn235 is expressed with a 6His tag at the C-terminus. Interleukin-10 Receptor alpha (IL-10Ra) is a transmembrane glycoprotein member of the class II cytokine receptor family. Mature human IL-10 Ra consists of a 214 amino acid (aa) extracellular domain (ECD); a 21 aa transmembrane segment; and a 322 aa cytoplasmic domain. Within the ECD; human IL-10 Ra shares 59% aa sequence identity with mouse and rat IL-10Ra. IL-10 Ra is required for mediating the effects of IL-10;a critical molecule in the control of microbial infections; allergic and autoimmune inflammation; and cancer. IL-10Ra is the ligand specific subunit of the IL-10 receptor complex. Noncovalent dimers of IL-10 bind to IL-10 Ra; resulting in the recruitment of IL-10 R beta. Immunosuppressive signal transduction through the IL-10 receptor complex can be inhibited by activation of TLR2; 4; or 9; enabling strengthened immune responses during infection. Polymorphisms of human IL-10 Ra may limit viral immune evasion by retaining full responsiveness to human IL-10 but responding weakly to the cytomegalovirus homolog of IL10.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Aliquoted proteins are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:download_pdf.php
