Recombinant Human Tryptase alpha/beta-1/TPSAB1 (C-6His)
Product Sizes
10 µg
£564.00
32-8840-10UG
50 µg
£857.00
32-8840-50UG
About this Product
- SKU:
- 32-8840
- Extra Details:
- Source: Human Cells. MW :28.8kD. Recombinant Human Tryptase alpha/beta-1 is produced by our Mammalian expression system and the target gene encoding Ile31-Pro275 is expressed with a 6His tag at the C-terminus. Tryptases are serine proteases with trypsin-like specificity. Together with chymases and Cathepsin G; tryptases are important players in mast cell mediation of inflammatory and allergic responses. Tryptase alpha/beta-1(TPSAB1); also known as mast cell protease 7 (MCPT7); it exhibits anticoagulant activity due to its ability to degrade fibrinogen in the presence of a diverse array of protease inhibitors in plasma. The two Isoform 1 and isoform 2 are expressed in lung; stomach; spleen; heart and skin; in these tissues; isoform 1 is predominant. Isoform 2 is expressed in aorta; spleen; and breast tumor; with highest levels in the endothelial cells of some blood vessels surrounding the aorta; as well as those surrounding the tumor and low levels; if any; in mast cells. Isoform 2 cleaves large substrates; such as fibronectin; more efficiently than isoform 1; but seems less efficient toward small substrates. It may play a role in innate immunity.
- Shipping Conditions:
- Dry Ice
- Storage Conditions:
- Lyophilized protein should be stored at -20[o]C; though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7[o]C for 2-7 days. Aliquots of reconstituted samples are stable at -20[o]C for 3 months.
- Supplier:
- Abeomics
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules:Recombinant Proteins
- Manufacturer's Data Sheet:TPSAB1.jpg
